孙超

　　

　　1．基本信息

　　孙超，男，汉族，陕西商南人，教授，博导。1989年9月-1993年7月在原西北农业大学畜牧专业上大学，毕业后留校任教至今；1995年9月-1998年7月在365官网攻读动物遗传育种硕士学位；1998年9月-2001年12月在365官网攻读动物遗传育种博士学位；1999年2月-2001年7月在第四军医大学细胞生物学实验室做合作研究；2001年12月晋升副教授；2003年5月被聘为硕士生导师；2003年9月-2006年7从本校生物学博士后流动站出站，2004年8月-2007年8月任学校实验室管理处副处长；2005年入选学校首批“青年学术骨干支持计划”，2006年5月由副教授直聘为博导，2007年入选教育部“新世纪优秀人才支持计划”，2008年10月晋升教授；2009年2月-2011年2月在美国宾夕法尼亚州立大学医学院肥胖与糖尿病研究中心做访问学者和博士后研究；2013年12月至今任动物科技学院副院长。

　　2．研究方向

　　动物脂质代谢的可塑性调控及其遗传机理、动物肉脂性状形成的分子遗传调控机理、肥胖症与糖尿病的发生机理及其防治、现代生物技术与动物分子育种。

　　3．开设课程

　　开展动物生物化学和分子生物学相关教学与科研工作，先后承担本科生《动物生物化学》、《分子生物学》等课程教学，为博、硕士研究生讲授《高级动物生化》、《蛋白质组学》等课程。带领“动物生物化学”教学团队获批2015年省级教学团队。

　　4．学术成果

　　现主持科研项目：

　　（1）猪肌内脂肪形成分子调控与新品种选育创新团队，陕西省重点科技创新团队建设项目（2017KCT-24），2017/01-2019/12，100万

　　（2）Leptin及相关因子调控猪脂肪发育的分子机制，973计划项目（2015CB943102），2016/01-2019/12，450万

　　（3）胶原XV通过“Ca2+-内质网”轴调节猪白色脂肪棕色化的作用机制，国家自然科学基金（31572365），2016/01-2019/12，76.8万

　　（4）猪脂肪沉积关键基因bambi的克隆及功能验证,农业部转基因重大专项，2014/01-2016/12，170万元

　　（5）生猪绿色安全养殖、疾病防控技术研究与示范，陕西省农业攻关项目， 2014/01-2016/12，8万元

　　（6）节能环保发酵床使用技术推广,陕西省农业专项，2014/1-2016/12，15万元

　　（7）αMSH通过PKA和ERK信号通路调节猪脂肪沉积和Leptin及Foxc2分泌的分子机制，国家自然科学基金（31172185），2014/01-2016/12，58.0万

　　近年发表主要论文：

　　（1）Lu Gan, Zhenjiang Liu, Fei Feng, Tianjiao Wu, Dan Luo, Chingyuan Hu, Chao Sun. (2017) Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice. International journal of obesity.In press

　　（2）Fei Feng, Qian Ren, Song Wu, Muhammad Saeed, Chao Sun. (2017) Hoxa5 Increases Mitochondrial Apoptosis by Inhibiting Akt/mTORC1/S6K1 Pathway in Mice White Adipocytes. Oncotarget. https://doi.org/10.18632/oncotarget.20521

　　（3）Guannv Liu, Meihang Li, Yatao Xu, Song Wu, Muhammad Saeed Chao Sun. (2017) ColXV Promotes Adipocyte Differentiation via Inhibiting DNA Methylation and cAMP/PKA Pathway in Mice. Oncotarget.; 8:60135-60148

　　（4）Weina Cao, Meihang Li, Tianjiao Wu, Fei Feng, Tongying Feng, Yang Xu and Chao Sun. (2017) αMSH prevents ROS-induced apoptosis by inhibiting Foxo1/mTORC2 in mice adipose tissue. Oncotarget.; 8:40872-40884.

　　（5）Zhenjiang Liu, Lu Gan, Yatao Xu, Dan Luo, Qian Ren, Song Wu, Chao Sun* (2017) Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue.. DOI: 10.1111/jpi.12414. Journal of Pineal Research.

　　（6）Guannv Liu, Meihang Li, Muhammad Saeed, Yatao Xu, Qian Ren, Chao Sun. (2017) αMSH Inhibits Adipose Inflammation via Reducing FoxOs Transcription and Blocking Akt/JNK Pathway in Mice. Oncotarget. 8:47642-47654

　　（7）Li M, Beauchemin H, Popovic N, Peterson A, d'Hennezel E, Piccirillo CA, Sun C, Polychronakos C. (2017) The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology. J Autoimmun. 22. pii: S0896-8411(16)30324-9.

　　（8）Liu Zhenjiang, Gu Huihui, Gan Lu, Xu Yatao, Feng Fei, Saeed Muhammad, Sun Chao. (2017) Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue. Oncotarget. Feb 7;8(6):9267-9279.

　　（9）Liu Zhenjiang, Gan Lu, Luo Dan, Sun Chao. (2017) Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue. Journal of Pineal Research. May;62(4)..

　　（10）Zhenjiang Liu, Lu Gan, Tianjiao Wu, Fei Feng, Dan Luo, Guannv Liu, Huihui Gu, Shimin Liu and Chao Sun*. (2016) Adiponectin reduces ER stress and apoptosis via PPARα transcriptional regulates ATF2 and AMPK/PKC signal in mice adipose. Cell death & disease. Nov 24;7(11):e2487.

　　（11）Lu Gan, Zhenjiang Liu,Tianjiao Wu, Fei Feng,Chao Sun*. (2017) αMSH promotes preadipocyte proliferation by alleviating ER stress-induced leptin resistance and by activating Notch1 signal in mice. BBA-Molecular Basis of Disease.,(16)30245-9.

　　（12）Lu Gan, Zhenjiang Liu, Yuzhe Chen, Dan Luo, Fei Feng, Guannv Liu, Chao Sun*. (2016) α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue. Sci Rep.  Nov 7;6:36661

　　（13）Liu Z, Gan L, Chen Y, Luo D, Zhang Z, Cao W, Zhou Z, Lin X, Sun C*. (2016) Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes. Sci Rep. 6:21382.

　　（14）Liu Z, Gan L, Liu G, Chen Y, Wu T, Feng F, Sun C*. (2016) Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice. J Lipid Res.  Jun 17. pii: jlr.M063537.

　　（15）Yang H, An JJ, Sun C*, Xu B.(2016)Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons.Mol Endocrinol. 30(5):494-503.

　　（16）Gan, L., Liu, Z.J., Cao, W.N., Zhang, Z.Z., Sun, C*. (2015). FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes. Scientific Reports. Aug 27;5:13588.

　　（17）Gan, L., Liu, Z.J., Jin, W., Zhou, Z.J., Sun, C*.(2015). Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes. Journal of Lipid Research, 56(8), 1471-1480.

　　（18）Gan, L, Yan, J, Liu, Z.J., Feng, M, Sun, C*. (2015) Adiponectin prevents reduction of lipid-induced mitochondrial biogenesis via AMPK/ACC2 pathway in chicken adipocytes. Journal of Cellular Biochemistry, 116(6), 1090-1100.

　　（19）Yan, Jun, Tan, Xiao, Yan, Guoyong, Feng, Min, Yang, Haili, Sun, C*. (2014). Recombinant Globular Adiponectin Inhibits Lipid Deposition by p38 MAPK/ATF-2 and TOR/p70 S6 Kinase Pathways in Chicken Adipocytes. Biochemistry and Cell Biology. 92(1):53-60.

　　（20）Gan, L., Liu, Z.J, Zhang, Z.Z., Yang, X.b., Liu, J., Sun, C*. (2014). SOCS2 inhibited mitochondria biogenesis via inhibiting p38 MAPK/ATF2 pathway in C2C12 cells. Molecular biology reports, 41(2), 627-637.

　　（21）Liu, Z.J, Gan, L., Yang, X.B., Zhang, Z.Z., Liu, J., Sun, C*. (2014).Hydrodynamic tail vein injection of SOCS3 eukaryotic expression vector in vivo promoted liver lipid metabolism and hepatocyte apoptosis in mouse. Biochemistry and Cell Biology. 92(2).

　　（22）Yan J., Gan L., Chen D., Sun C*. (2013) Adiponectin impairs chicken preadipocytes differentiation through p38 MAPK/ATF-2 and TOR/p70 S6 Kinase pathways. PLOS ONE. 10.1371/journal.pone.0077716

　　（23）Yan J., Gan L., Qi R.L.Sun C*. (2013) Adiponectin decreases lipids deposition by p38 MAPK/ATF2 signaling pathway in muscle of broilers. Molecular Biology Reports, 40(12):7017-25. doi: 10.1007

　　（24）Jiang D.F., Zhang X.G., Yang H.L., Sun C*. (2013). Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine. Genetics and Molecular Research. doi:10.4238

　　（25）Yan J., Yang H.L., Gan L., Sun C*. (2013). Adiponectin-impaired adipocyte differentiation negatively regulates fat deposition in chicken. Journal of Animal Physiology and Animal Nutrition. doi: 10.1111/jpn.12107

　　（26）Yang H.L., Feng M, Tan X, Yan G.Y., Gan L, Sun C*. (2013). Construction of suppressor of cytokine signaling 2 (SOCS2) adenoviral overexpression vector and its impact on growth-hormone-induced lipolysis in swine primary adipocytes. Genetics and Molecular Research, 12(2), 1283-1293.

　　（27）Li, Y., Ohms, S. J., Sun, C*., & Fan, J. Y. (2013). NF-kappa B controls Il2 and Csf2 expression during T cell development and activation process. Molecular Biology Reports, 40(2), 1685-1692. doi: 10.1007/s11033-012-2219-2

　　（28）Qi, R. L., Feng, M., Tan, X., Gan, L., Yan, G. Y., Sun, C*. (2013). FATP1 silence inhibits the differentiation and induces the apoptosis in chicken preadipocytes. Molecular Biology Reports, 40(4), 2907-2914.

　　（29）Yan, J., Gan, L., Yang, H. L., Sun, C*. (2013). The proliferation and differentiation characteristics of co-cultured porcine preadipocytes and muscle satellite cells in vitro. Molecular Biology Reports, 40(4), 3197-3202. doi: 10.1007/s11033-012-2395-0

　　（30）Yang, H. L., Feng, M., Tan, X., Yan, G. Y., Sun, C*. (2013). The role of SOCS2 in recombinant human growth hormone (rhGH) regulating lipid metabolism in high-fat-diet-induced obesity mice. Molecular Biology Reports, 40(3),2319-2326.

　　（31）Zhao, Xia, Qi, Renli, Sun, Chao*, Xie, Yunfei.(2013) Silencing SOCS3 could inhibit TNF-alpha induced apoptosis in 3T3-L1 and mouse preadipocytes. Molecular Biology Reports, 39(9): 8853-8860, 2012/9.

　　（32）Sun, C*., Tian, L., Nie, J., Zhang, H., Han, X., Shi, Y. G. (2012). Inactivation of MARK4, an AMP-activated Protein Kinase (AMPK)-related Kinase, Leads to Insulin Hypersensitivity and Resistance to Diet-induced Obesity. Journal Of Biological Chemistry,287(45).doi: 10.1074/jbc.M112.388934

　　（33）Nie, J., Sun, C., Faruque, O., Ye, G. M., Li, J., Liang, Q. R., Shi, Y. G. (2012). Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-stimulated Insulin Secretion through Activation of p21-activated Kinase (PAK1) in Pancreatic beta-Cells. Journal Of Biological Chemistry, 287(31), 26435-26444. doi: 10.1074/jbc.M112.378372

　　（34）Sun, Chao*, Qi, Renli, Wang, Li, Yan, Jun, Wang, Yong. p38 MAPK regulates calcium signal-mediated lipid accumulation through changing VDR expression in primary preadipocytes of mice. Molecular Biology Reports, 39(3): 3179-3184, 2012/3

　　（35）Sun, Chao*, Wang, Li, Yan, Jun, Liu, Shumin. (2012). Calcium ameliorates obesity induced by high-fat diet and its potential correlation with p38 MAPK pathway Molecular Biology Reports, 39(2): 1755-1763, 2012/2.

　　（36）Renli, Q., Chao, S.*, Jun, Y., Chan, S., &Yunfei, X. (2012). Changes in fat metabolism of black-bone chickens during early stages of infection with Newcastle disease virus. Animal, 6(8), 1246-1252. doi: 10.1017/s1751731112000365

　　（37）Li, Y., Chen, G. B., Ma, L. N., Ohms, S. J., Sun, C*., Shannon, M. F., Fan, J. Y. (2012). Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Molecular Biology, 13. doi: 10.1186/1471-2199-13-16

　　（38）Li, Y., Ohms, S. J., Shannon, F. M., Sun, C*., Fan, J. Y. (2012). IL-2 and GM-CSF are regulated by DNA demethylation during activation of T cells, B cells and macrophages. Biochemical And Biophysical Research Communications, 419(4), 748-753. doi: 10.1016/j.bbrc.2012.02.094

　　（39）Liu, J., Jing, X. B., Gan, L., Sun, C*. (2012). The JAK2/STAT3 Signal Pathway Regulates the Expression of Genes Related to Skeletal Muscle Development and Energy Metabolism in Mice and Mouse Skeletal Muscle Cells. Bioscience Biotechnology And Biochemistry, 76(10), 1866-1870. doi: 10.1271/bbb.120324

　　（40）Yang, H. L., Sun, C*., Sun, C., & Qi, R. L. (2012). Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte. Molecular Biology Reports, 39(9), 9113-9122. doi: 10.1007/s11033-012-1783-9

　　（41）Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y. (2010). Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell metabolism, 12(2), 154-165.

　　获得科研奖励

　　(1) Leptin调控脂肪细胞发育与代谢的分子机制，吴常信动物遗传育种科技成果奖， 2015，排名1；

　　(2) 西北五省区重要地方畜禽遗传资源研究，陕西省人民政府，陕西省科学技术奖，二等，2012，排名3；

　　(3) 猪脂肪沉积及其调控机制研究，陕西省人民政府，陕西省科学技术奖，三等，2016，排名4；

　　5．联系方式

　　通讯地址：陕西杨凌西农路22号 365官网动物科技学院

　　邮编：712100

　　联系电话：029-87092158（办）

　　Email: sunchao2775@163.com